In this fireside chat, Dr. Emanuel Della Torre (Rheumatologist, San Raffaele Hospital, Milan) and Dr. Emma Culver (Hepatologist & Gastroenterologist, John Radcliffe Hospital, Oxford) discuss how IgG4-related disease (IgG4-RD) affects the pancreas and bile ducts. Gain insights into diagnosis, treatment approaches (including corticosteroids and B-cell depletion), and lifestyle tips that can support long-term management for those living with IgG4-RD.

Topics Covered

Key symptoms of pancreatic and biliary involvement, such as abdominal pain, jaundice, and weight loss
How to differentiate autoimmune pancreatitis from other serious conditions (e.g., pancreatic cancer)
Various treatment strategies: steroids, immunosuppressants, bile duct stenting
Lifestyle recommendations: nutrition, exercise, smoking cessation, and supplements
Audience Q&A on enzyme therapy duration, exocrine insufficiency, SIBO, and more

Chapters

0:00 Introduction and Welcome
1:00 IgG4ward! Announcements
2:10 Why Pancreas & Bile Ducts Matter in IgG4-RD
3:27 Dr. Culver’s Presentation: Anatomy & Function
6:19 Pancreas and the bile ducts what are their function, and where are they?
10:20 What are the symptoms and signs of IgG4-RD of the pancreas and bile ducts?
15:10 Getting it Right: The correct diagnosis
20:00 Treatment, When and How?
26:56 Treatment – Endoscopy and Stents
28:46 Improving the Function of the Organs
32:07 Pancreas Scarring, Stones and Calcifications
34:52 Lifestyle and Supplements
37:50 Monitoring Bone Health
39:00 Managing Symptoms & Anxiety
40:30 Key Takeaways
41:45 Q&A
1:07:36 Closing Remarks

#IgG4RD #PancreaticHealth #BiliaryDisease #AutoimmunePancreatitis #healthcare